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CVE-2026-54604· NVD / CVE Program· CNA GitHub_M

OpenSlide: openslide_read_region() returns uninitialized memory with libtiff 4.7.1

OpenSlide is a C library for reading whole slide image files. Prior to 4.0.1, a behavior change in libtiff 4.7.1 causes the indirect TIFF tile path in src/openslide-decode-tiff.c and _openslide_tiff_read_tile() to request a full-height destination for a partial bottom tile row, allowing uninitialized heap memory to enter pixel data returned by openslide_read_region(). A crafted but valid slide can trigger the issue in TIFF-based formats other than Hamamatsu NDPI when a network service renders attacker-provided slides. Successful extraction depends on pixel transparency handling and recompression, OpenSlide with libtiff 4.7.0 or earlier is not affected, and official binary builds 4.0.0.10 and 4.0.0.11 are affected. This issue is fixed in OpenSlide 4.0.1 and official binary build 4.0.0.12.

MediumCVSS 5.3 · v4.0—No exploit Fix available
Published
Sep 17, 2026
Updated
Sep 23, 2026
EPSS
0.5% · 42th percentile
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Report tools

JSON

Action score

21

Monitor

Low priority for now.

CVSS
21 / 40 · 5.3 / 10
CISA KEV
0 / 30 · Not listed
EPSS
0 / 30 · 0.5%

CISA SSVC decision

Exploitation
none
Automatable
no
Technical impact
partial

Vulnrichment: CISA's decision-tree inputs.

CNA vs NVD score

NVD
—
CNA · GitHub_M
5.3
NVD has not scored this yet; the score shown is the CNA’s.

CVSS:4.0/AV:N/AC:L/AT:N/PR:L/UI:N/VC:L/VI:N/VA:N/SC:N/SI:N/SA:N

The score given by the assigning authority versus NVD’s independent score. A gap means the severity is contested.

Affected systems

—

Versions reported by the vendor

Affected version ranges reported by the assigning authority (GitHub_M). Independent of NVD's CPE analysis and usually ahead of it.

  • openslide openslide

    • < 4.0.1affected

Package-level exposure

OSV and GitHub Advisory data: ecosystem, package and range. SBOM matching uses this table.

EcosystemPackageAffected rangeFix
Debian:12openslideall versions—
Debian:14openslidebefore 4.0.1+dfsg-14.0.1+dfsg-1

Same product

openslide: all records

Other highest-scoring records for the same primary product.

  • CVE-2026-48977OpenSlide: Arbitrary memory write with crafted Ventana BIF file
    30Monitor

Remediation

Which version to upgrade to

Fix versions compiled from the vendor, package registries and Microsoft. Verify the vendor's note before upgrading.

Product / packageFixed versionSource
debian:openslide4.0.1+dfsg-1 · Debian:14Package registry (OSV)

Exploit status

No known public exploit

No public exploit has been observed yet. That doesn't mean you're safe, only that the bar is a little higher.

Research context

For pentesters and researchers: attack profile, score disagreement, timeline, patch commits, credits, variant and chain candidates, bug bounty scope. All derived from existing data; no exploit code.

Timeline

From publication to today: proof of concept, Metasploit module, CISA KEV and fix record. Dates are as reported by the sources.

No dated events beyond publication.

EPSS, last 120 days

FIRST EPSS daily score; only changes of 0.01 or more are recorded (step chart).

Patch and commit links

Commit, PR and diff links among the references. A starting point for patch-diffing and variant hunting; fixes, not exploits.

Credits

All researchers

Finders, reporters and analysts named in the CNA record. Click a name for that researcher’s other records.

No credits in the CNA record.

Variant candidates

Same product, same weakness class, within 18 months. If the patch missed the root cause, the sibling bug is here.

No nightly-computed relations.

Chain candidates

An authentication bypass and a privilege-requiring bug in the same product, published close together: combined they may become an unauthenticated path.

—

Bug bounty scope

No known public program.

Source: bounty-targets-data (public HackerOne, Bugcrowd, Intigriti, YesWeHack listings).

Technical details

Attack conditions

  • Anyone who can reach it over the internet can trigger it.
  • A low-privileged account is enough.
  • No user action is required.
  • No special conditions are required; it is repeatable.

If successful

Confidentiality
Integrity
Availability
Attack vector
Network
Attack complexity
Low
Privileges required
Low
User interaction
None
Scope
X

Weakness class (CWE)

CWE-758 · Reliance on Undefined, Unspecified, or Implementation-Defined Behavior

CVSS vector

CVSS:4.0/AV:N/AC:L/AT:N/PR:L/UI:N/VC:L/VI:N/VA:N/SC:N/SI:N/SA:N/E:X/CR:X/IR:X/AR:X/MAV:X/MAC:X/MAT:X/MPR:X/MUI:X/MVC:X/MVI:X/MVA:X/MSC:X/MSI:X/MSA:X/S:X/AU:X/R:X/V:X/RE:X/U:X

nvd-secondary

Attack context

MITRE CAPEC attack patterns and ATT&CK techniques for this weakness class (CWE). A starting point for detection rules and threat hunting.

MITRE has no CAPEC/ATT&CK mapping for this CWE.

Noroxi analysis

No Noroxi analysis for this record yet

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Change log

  1. Fix✗ → ✓

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References

Vendor advisories and official records. Exploit/PoC links are deliberately left out.

All records